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When Resectability Emerges After Systemic Therapy in Hepatocellular Carcinoma: A Proposed Response-Guided Consolidation Framework.

Immune checkpoint inhibitor-based combination therapies have increased the likelihood that a subset of patients with initially unresectable hepatocellular carcinoma (HCC) may achieve sufficient tumor …

Thérapies de Conversion

Cheng, Y., & Xie, K. (2026). When Resectability Emerges After Systemic Therapy in Hepatocellular Carcinoma: A Proposed Response-Guided Consolidation Framework.. J Hepatocell Carcinoma, 13, 613934. https://doi.org/10.2147/JHC.S613934

01/01/2026 Lire →

From centripetal to centrifugal: pathological regression patterns after neoadjuvant or conversion therapy as markers of nodal risk and a framework for future research on individualized lymphadenectomy in gastric cancer.

OBJECTIVE: To analyze the relationship between tumor regression patterns and ypN positivity and explore their implications for postoperative nodal-risk stratification after neoadjuvant or conversion t…

Thérapies de Conversion

Li, N., Liu, P., Guo, J., Wang, J., Zhao, G., Mou, Z., & Mao, J. (2026). From centripetal to centrifugal: pathological regression patterns after neoadjuvant or conversion therapy as markers of nodal risk and a framework for future research on individualized lymphadenectomy in gastric cancer.. Front Immunol, 17, 1766242. https://doi.org/10.3389/fimmu.2026.1766242

01/01/2026 Lire →

From Control to Conversion: Optimizing Systemic Therapy for Curative-Intent Conversion Surgery in Metastatic Gastric Cancer.

Conversion therapy enables curative-intent resection in patients with initially unresectable or metastatic cancers after effective systemic therapy. Recently, advances in systemic therapy with molecul…

Thérapies de Conversion

Han, H. S., & Rha, S. Y. (2026). From Control to Conversion: Optimizing Systemic Therapy for Curative-Intent Conversion Surgery in Metastatic Gastric Cancer.. J Gastric Cancer, 26(1), 146-160. https://doi.org/10.5230/jgc.2026.26.e8

01/01/2026 Lire →

A Qualitative Double Perspective Investigation of Sexual Orientation Change Efforts Among Homosexual Individuals in Tunisia.

Despite the condemnation of the major medical and psychological institutions, which warn of the significant harm associated with sexual orientation change efforts, these practices persist in certain c…

Thérapies de Conversion

Mahjoubi, H., Mtiraoui, A., & Préau, M. (2026). A Qualitative Double Perspective Investigation of Sexual Orientation Change Efforts Among Homosexual Individuals in Tunisia.. J Homosex, 73(5), 1270-1290. https://doi.org/10.1080/00918369.2025.2503407

01/01/2026 Lire →

Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study.

BACKGROUND: Patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) face limited treatment options and poor outcomes. Preclinical evidence supports chemoimmunotherapy as …

Thérapies de Conversion

Zhu, J., Zhang, J., Ling, X., Wang, C., Yang, Y., Xin, Y., Jiang, H., Liang, H., Zhang, L., Qin, X., Lei, J., Fang, C., Yang, X., Wang, Y., Meng, W., Wang, X., Meng, H., & Ma, J. (2025). Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study.. BMC Med, 24(1), 59. https://doi.org/10.1186/s12916-025-04592-z

28/12/2025 Lire →

Prognostic significance of Albumin-Bilirubin score changes in patients treated with systemic therapy for recurrent hepatocellular carcinoma after liver resection.

PURPOSE: To clarify the characteristics of patients who received systemic therapy for recurrent hepatocellular carcinoma after liver resection and evaluate the associated prognostic factors.METHODS: W…

Thérapies de Conversion

Asahi, Y., Kakisaka, T., Orimo, T., Shimada, S., Nagatsu, A., Aiyama, T., Fujiyoshi, S., Sakamoto, Y., Fujii, Y., Yoshida, Y., Shichi, S., Imaizumi, K., & Taketomi, A. (2025). Prognostic significance of Albumin-Bilirubin score changes in patients treated with systemic therapy for recurrent hepatocellular carcinoma after liver resection.. Surg Today. https://doi.org/10.1007/s00595-025-03217-5

24/12/2025 Lire →

The effectiveness and safety of immune checkpoint inhibitors in conversion or neoadjuvant therapy for hepatocellular carcinoma: a meta-analysis and systematic review.

BACKGROUND: The adoption of immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) and/or local therapy, including transarterial chemoembolization (TACE) and hepatic arteri…

Thérapies de Conversion

Hu, L., Xu, Y., Qiao, Y., Wang, A., He, C., & Wang, R. (2025). The effectiveness and safety of immune checkpoint inhibitors in conversion or neoadjuvant therapy for hepatocellular carcinoma: a meta-analysis and systematic review.. BMC Cancer, 26(1), 163. https://doi.org/10.1186/s12885-025-15449-2

23/12/2025 Lire →

Resection versus microwave ablation following conversion therapy for unresectable hepatocellular carcinoma.

BACKGROUND AIMS: Conversion therapy may transform some unresectable hepatocellular carcinomas (uHCCs) into curable ones, but data remained limited comparing subsequent curative-intent treatment option…

Thérapies de Conversion

Jiang, H., Zuo, M., Wei, R., Han, J., Yao, W., Li, W., Fu, Y., Liu, W., Li, C., Lee, S., Ronot, M., Song, B., An, C., & Wu, P. (2025). Resection versus microwave ablation following conversion therapy for unresectable hepatocellular carcinoma.. Int J Surg. https://doi.org/10.1097/JS9.0000000000004486

16/12/2025 Lire →

Advances in the management of ovarian cancer liver metastasis.

Liver metastasis represents a critical challenge in cancer progression, with particularly complex therapeutic implications. In ovarian cancer patients, ovarian cancer liver metastasis (OCLM) marks a d…

Thérapies de Conversion

Li, H., Feng, Y., Wang, Z., & Li, X. (2025). Advances in the management of ovarian cancer liver metastasis.. Int J Cancer, 157(12), 2423-2433. https://doi.org/10.1002/ijc.70065

15/12/2025 Lire →

Clinical Significance of Intratumoral Contrast Pooling on Contrast-Enhanced CT After Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma.

Recent advances in systemic therapies have improved clinical outcomes for patients with unresectable hepatocellular carcinoma (uHCC), as shown in randomized phase 3 clinical trials. Given the availabi…

Thérapies de Conversion

Minamiguchi, K., Irizato, M., Nakano, R., Kunichika, H., Tachiiri, T., Taiji, R., Tsuji, Y., Yasuda, S., Yoshiji, H., Sho, M., & Tanaka, T. (2025). Clinical Significance of Intratumoral Contrast Pooling on Contrast-Enhanced CT After Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma.. Curr Oncol, 32(12). https://doi.org/10.3390/curroncol32120694

09/12/2025 Lire →

Screening HCC Patients Who Can Benefit from the Sequential Treatment of Conversion Therapy and Radical Surgery and Constructing a Predictive Model.

BACKGROUND/OBJECTIVE: This study aimed to develop a new nomogram to predict the likelihood of benefit for patients with advanced HCC who can benefit from the sequential treatment of conversion therapy…

Thérapies de Conversion

Liu, L., Qin, C., Lei, K., Zhang, H., & Zhang, W. (2025). Screening HCC Patients Who Can Benefit from the Sequential Treatment of Conversion Therapy and Radical Surgery and Constructing a Predictive Model.. Cancers (Basel), 17(24). https://doi.org/10.3390/cancers17243928

08/12/2025 Lire →

Safety and efficacy of salvage surgery for unresectable hepatocellular carcinoma after conversion with triple therapy: a systematic review and meta-analysis of data from Chinese patients.

BACKGROUND: Conversion therapy based on vascular intervention combined with targeted immunotherapy has gradually improved treatment outcomes for hepatocellular carcinoma (HCC). Salvage surgery after c…

Thérapies de Conversion

Pang, Q., Mo, X., Tang, Z., Wei, M., Liu, D., Zhou, Z., Huang, B., Bai, T., Wang, X., & Wu, F. (2025). Safety and efficacy of salvage surgery for unresectable hepatocellular carcinoma after conversion with triple therapy: a systematic review and meta-analysis of data from Chinese patients.. World J Surg Oncol, 24(1), 21. https://doi.org/10.1186/s12957-025-04122-4

02/12/2025 Lire →