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Comparison of survival benefit and safety between surgery following conversion therapy versus surgery alone in patients with surgically resectable hepatocellular carcinoma at CNLC IIb/IIIa stage: a propensity score matching study.

OBJECTIVE: The objective of this study is to evaluate and compare the survival benefit and safety of surgery following conversion therapy versus surgery alone in patients diagnosed with surgically res…

Thérapies de Conversion

Ma, Z., Xiao, Z., Yin, P., Wen, K., Wang, W., Yan, Y., Lin, Z., Li, Z., Wang, H., Zhang, J., & Mao, K. (2024). Comparison of survival benefit and safety between surgery following conversion therapy versus surgery alone in patients with surgically resectable hepatocellular carcinoma at CNLC IIb/IIIa stage: a propensity score matching study.. Int J Surg, 110(5), 2910-2921. https://doi.org/10.1097/JS9.0000000000001193

01/05/2024 Lire →

Watch-and-wait strategy vs. resection in patients with radiologic complete response after conversion therapy for initially unresectable hepatocellular carcinoma: a propensity score-matching comparative study.

BACKGROUND: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unc…

Thérapies de Conversion

Li, B., Wang, C., He, W., Qiu, J., Zheng, Y., Zou, R., Lin, Z., Shi, Y., Yuan, Y., Zhang, R., Zhang, C., Chen, M., Lau, W. Y., & Yuan, Y. (2024). Watch-and-wait strategy vs. resection in patients with radiologic complete response after conversion therapy for initially unresectable hepatocellular carcinoma: a propensity score-matching comparative study.. Int J Surg, 110(5), 2545-2555. https://doi.org/10.1097/JS9.0000000000001155

01/05/2024 Lire →

Outcomes of Salvage Surgery Versus Non-Salvage Surgery for Initially Unresectable Hepatocellular Carcinoma After Conversion Therapy with Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Antibody: A Multicenter Retrospective

BACKGROUND: Combination treatment with transcatheter arterial chemoembolization (TACE), lenvatinib, and anti-programmed death-1 (anti-PD-1) antibodies (triple therapy) has a high rate of tumor respons…

Thérapies de Conversion

Wu, J. Y., Wu, J. Y., Fu, Y. K., Ou, X. Y., Li, S. Q., Zhang, Z. B., Zhou, J. Y., Li, B., Wang, S. J., Chen, Y. F., & Yan, M. L. (2024). Outcomes of Salvage Surgery Versus Non-Salvage Surgery for Initially Unresectable Hepatocellular Carcinoma After Conversion Therapy with Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Antibody: A Multicenter Retrospective. Ann Surg Oncol, 31(5), 3073-3083. https://doi.org/10.1245/s10434-024-14944-3

01/05/2024 Lire →

Evaluation of the efficacy and safety of ramucirumab combined with nab-paclitaxel, lobaplatin, and S-1 in neoadjuvant and conversion therapy for advanced gastric cancer: A study protocol of prospective single-center, randomized controlled and open label c

OBJECTIVE: Ramucirumab is a VEGFR2 antagonist. The aim of this trial is to evaluate the efficacy and safety of ramucirumab combined with nab-paclitaxel, lobaplatin and S-1 in neoadjuvant and conversio…

Thérapies de Conversion

Wang, J., Xu, G., Liu, S., Ma, Y., Wang, S., Li, M., Zhao, Y., Wang, H., Wang, Y., Peng, C., Huo, H., Li, H., Ji, G., & Yang, J. (2024). Evaluation of the efficacy and safety of ramucirumab combined with nab-paclitaxel, lobaplatin, and S-1 in neoadjuvant and conversion therapy for advanced gastric cancer: A study protocol of prospective single-center, randomized controlled and open label c. Heliyon, 10(8), e29485. https://doi.org/10.1016/j.heliyon.2024.e29485

30/04/2024 Lire →

Surgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study.

Systemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some patients may achieve partial response (PR) or complete respons…

Thérapies de Conversion

Zhang, X., Zhu, X., Zhong, J., Zhao, Y., Zhang, X., Zhang, W., Ye, F., Yang, C., Xue, J., Xiong, R., Wang, J., Shen, S., Pan, Y., Li, D., Song, T., Bi, X., Sun, H., Xiang, B., Gu, S., … Cai, J. (2024). Surgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study.. Sci Rep, 14(1), 9745. https://doi.org/10.1038/s41598-024-60379-x

28/04/2024 Lire →

Multimodal Treatment of Metastatic Rectal Cancer in a Young Patient: Case Report and Literature Review.

Metastatic colorectal cancer requires a multidisciplinary and individualized approach. Herein, we reported the case of a young woman diagnosed with metastatic rectal cancer who received an individuali…

Thérapies de Conversion

Popescu, I., Dudău, A. M., Dima, S., Herlea, V., Croitoru, V. M., Dinu, I. M., Miron, M., Lupescu, I., Croitoru-Cazacu, I. M., Dumitru, R., & Croitoru, A. E. (2024). Multimodal Treatment of Metastatic Rectal Cancer in a Young Patient: Case Report and Literature Review.. Medicina (Kaunas), 60(5). https://doi.org/10.3390/medicina60050696

24/04/2024 Lire →

[Consensus on the rational implementation of laparoscopic surgery after conversion therapy in far-advanced gastric cancer (first edition)].

Far-advanced gastric cancer has always been a challenging problem in clinical treatment and a key direction for breakthrough research. Non-surgical treatments are primarily managed in patients with fa…

Thérapies de Conversion

Beijing, G. a. s. t. r. i. c. . C. a. n. c. e. r. . Q. u. a. l. i. t. y. . C. o. n. t. r. o. l. . E. x. p. e. r. t. . C. o. m. m. i. t. t. e. e. (2024). [Consensus on the rational implementation of laparoscopic surgery after conversion therapy in far-advanced gastric cancer (first edition)].. Zhonghua Yi Xue Za Zhi, 104(16), 1381-1390. https://doi.org/10.3760/cma.j.cn112137-20231018-00811

23/04/2024 Lire →

Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of literature.

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes of death due to its complexity, heterogeneity, rapid metastasis and easy recurrence after surgical resection. We demonstrated th…

Thérapies de Conversion

Chu, J. H., Huang, L. Y., Wang, Y. R., Li, J., Han, S. L., Xi, H., Gao, W. X., Cui, Y. Y., & Qian, M. P. (2024). Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of literature.. World J Gastrointest Oncol, 16(4), 1647-1659. https://doi.org/10.4251/wjgo.v16.i4.1647

15/04/2024 Lire →

Prognoses of Patients Treated With Surgical Therapy Versus Continuation of Local-Plus-Systemic Therapy Following Successful Down-Staging of Intermediate-Advanced Hepatocellular Carcinoma: A Multicenter Real-World Study.

BACKGROUND: The difference in the prognoses between treatment with surgical therapy and continuation of local-plus-systemic therapy following successful down-staging of intermediate-advanced hepatocel…

Thérapies de Conversion

Liu, J., Zhu, X., Pan, Y., Zhong, J., Jin, R., Zheng, X., Zhang, W., Hu, K., Ma, J., Shi, X., Liu, H., Yang, X., Xu, D., Ma, C., Chen, J., Wang, D., Wang, X., Li, Z., Zhao, L., … Wang, K. (2024). Prognoses of Patients Treated With Surgical Therapy Versus Continuation of Local-Plus-Systemic Therapy Following Successful Down-Staging of Intermediate-Advanced Hepatocellular Carcinoma: A Multicenter Real-World Study.. Oncologist, 29(4), e487-e497. https://doi.org/10.1093/oncolo/oyad277

04/04/2024 Lire →

Affirming Everyone in the Rainbow: Is Gender-Affirming Healthcare "Gay Conversion Therapy?".

Many young people today embrace gender-diverse identities, with adolescents and young adults comprising the largest and fastest-growing demographic of gender-affirming healthcare seekers. Simultaneous…

Thérapies de Conversion

MacKinnon, K. R., Expósito-Campos, P., Kinitz, D. J., & Bonifacio, J. (2024). Affirming Everyone in the Rainbow: Is Gender-Affirming Healthcare "Gay Conversion Therapy?".. Healthc Pap, 22(1), 55-62. https://doi.org/10.12927/hcpap.2024.27385

01/04/2024 Lire →

Expanding Policy and Programming to Address Conversion Therapy and 2SLGBTQ+ Health Inequity: A Discussion of Challenges.

Advocates and researchers have made myriad recommendations to guide policy actors in stopping conversion therapy. This commentary extends these recommendations by identifying core challenges that poli…

Thérapies de Conversion

Kinitz, D. J., Tran, N. K., & MacKinnon, K. R. (2024). Expanding Policy and Programming to Address Conversion Therapy and 2SLGBTQ+ Health Inequity: A Discussion of Challenges.. Healthc Pap, 22(1), 46-54. https://doi.org/10.12927/hcpap.2024.27386

01/04/2024 Lire →

[Advancements and controversies in conversion therapy for biliary tract malignant tumors with insufficient future liver remnant].

Due to the unique location and aggressive tumor biology,hilar cholangiocarcinoma,intrahepatic cholangiocarcinoma,and gallbladder cancer often present with obstructive jaundice and require extensive li…

Thérapies de Conversion

Wang, Z., & Hong, D. F. (2024). [Advancements and controversies in conversion therapy for biliary tract malignant tumors with insufficient future liver remnant].. Zhonghua Wai Ke Za Zhi, 62(4), 284-289. https://doi.org/10.3760/cma.j.cn112139-20231218-00283

01/04/2024 Lire →