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The Role of High-Intensity Focused Ultrasound as a Local Consolidative Therapy in Multimodal Conversion Treatment for Colorectal Liver Metastases: A Case Series.

IntroductionThis retrospective case series evaluated the feasibility, safety, and potential clinical role of high-intensity focused ultrasound (HIFU) as local consolidative therapy (LCT) in patients w…

Thérapies de Conversion

Du, G., Li, J., Wang, J., Zhang, L., Xu, Y., Yu, N., Li, L., Liu, H., Liu, Q., Song, J., Qiu, W., & Wang, S. (2026). The Role of High-Intensity Focused Ultrasound as a Local Consolidative Therapy in Multimodal Conversion Treatment for Colorectal Liver Metastases: A Case Series.. Technol Cancer Res Treat, 25, 15330338261461451. https://doi.org/10.1177/15330338261461451

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The survival impact of upfront or sequential chemoradiotherapy in locally advanced esophageal squamous cell carcinoma.

BACKGROUND: The treatment of locally advanced unresectable esophageal squamous cell carcinoma (ESCC) is a clinical challenge with limited therapeutic consensus. The immune checkpoint inhibitor (ICI)-b…

Thérapies de Conversion

Luo, X., Peng, F., Lin, X., Li, Y., & Ding, Z. (2026). The survival impact of upfront or sequential chemoradiotherapy in locally advanced esophageal squamous cell carcinoma.. Front Oncol, 16, 1785745. https://doi.org/10.3389/fonc.2026.1785745

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Gastric cancer, what's new from International Gastric Cancer Congress (IGCC) in Amsterdam: a scientific report from Salerno 2025 conference.

This paper presents a critical synthesis of the national conference "Gastric Cancer at Ruggi d'Aragona", held in Salerno, Italy, in June 2025. The event gathered over 200 specialists to discuss recent…

Thérapies de Conversion

Cattel, D., Albano, P. V., Feo, R., Pepe, S., & Puzziello, A. (2026). Gastric cancer, what's new from International Gastric Cancer Congress (IGCC) in Amsterdam: a scientific report from Salerno 2025 conference.. Ecancermedicalscience, 20, 2083. https://doi.org/10.3332/ecancer.2026.2083

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Hepatitis B virus infection and outcomes of TACE plus lenvatinib and PD-1 inhibitor therapy in unresectable hepatocellular carcinoma: a real-world propensity score-matched study.

BACKGROUND: The combination of transarterial chemoembolization (TACE), lenvatinib, and PD-1 inhibitors has shown promising efficacy in treating advanced hepatocellular carcinoma (HCC). However, the im…

Thérapies de Conversion

Su, Y., Liang, Y., Zhong, D., Chen, Y., Ma, S., Wang, M., Yang, Q., Yan, H., & Huang, X. (2026). Hepatitis B virus infection and outcomes of TACE plus lenvatinib and PD-1 inhibitor therapy in unresectable hepatocellular carcinoma: a real-world propensity score-matched study.. Front Immunol, 17, 1808956. https://doi.org/10.3389/fimmu.2026.1808956

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TACE plus lenvatinib and envafolimab for conversion therapy in unresectable HCC: a prospective pilot study.

BACKGROUND: Most patients with hepatocellular carcinoma (HCC) are diagnosed at intermediate or advanced stages, when curative resection is not feasible. Conversion therapy aiming to downstage tumors a…

Thérapies de Conversion

Su, Y., Liang, Y., Zhong, D., Chen, Y., Wang, M., Yang, Q., Yan, H., & Huang, X. (2026). TACE plus lenvatinib and envafolimab for conversion therapy in unresectable HCC: a prospective pilot study.. Front Immunol, 17, 1802197. https://doi.org/10.3389/fimmu.2026.1802197

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The Impact of Spatiotemporal Patterns of Tumor Recurrence on Prognosis in Hepatocellular Carcinoma Patients Undergoing Surgery After Conversion Therapy.

PURPOSE: To characterize the spatiotemporal patterns of recurrence and assess their impact on survival in hepatocellular carcinoma (HCC) patients undergoing curative resection after conversion therapy…

Thérapies de Conversion

Chen, Z., Zheng, H., Piao, M., Zhang, L., Sun, Y., Zhang, K., Zhang, J., Liu, Y., Xu, Y., & Lu, X. (2026). The Impact of Spatiotemporal Patterns of Tumor Recurrence on Prognosis in Hepatocellular Carcinoma Patients Undergoing Surgery After Conversion Therapy.. J Hepatocell Carcinoma, 13, 599046. https://doi.org/10.2147/JHC.S599046

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Massive Hepatocellular Carcinoma with Insufficient Future Liver Remnant Achieved Complete Response After Two-Stage Hepatectomy Combined with Hepatic Arterial Infusion Chemotherapy and Lenvatinib-sintilimab: A Case Report.

Massive hepatocellular carcinoma (HCC) is not suitable for radical surgery due to the factors of high tumor burden and poor postoperative liver function tolerance. There are few reports on the convers…

Thérapies de Conversion

Xu, R., Zhang, M., Zeng, Z., Wei, Y., Liao, X., Yang, C., Peng, T., & Su, H. (2026). Massive Hepatocellular Carcinoma with Insufficient Future Liver Remnant Achieved Complete Response After Two-Stage Hepatectomy Combined with Hepatic Arterial Infusion Chemotherapy and Lenvatinib-sintilimab: A Case Report.. Pharmgenomics Pers Med, 19, 578577. https://doi.org/10.2147/PGPM.S578577

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Pathologic response and safety of preoperative treatment regimens in gastric cancer undergoing D2 gastrectomy: a real-world cohort study.

OBJECTIVE: To compare pathological response and safety among three preoperative treatment regimens-chemotherapy alone, chemotherapy plus immunotherapy, and chemotherapy plus immunotherapy and targeted…

Thérapies de Conversion

Liu, P., Li, N., Guo, J., Wang, J., Wang, Z., Zhao, G., Mou, Z., & Mao, J. (2026). Pathologic response and safety of preoperative treatment regimens in gastric cancer undergoing D2 gastrectomy: a real-world cohort study.. Front Immunol, 17, 1766793. https://doi.org/10.3389/fimmu.2026.1766793

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Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs.

OBJECTIVE: To compare overall survival (OS) and progression-free survival (PFS) between surgical resection and non-surgical therapy in initially unresectable Cholangiocarcinoma (CCA) patients who achi…

Thérapies de Conversion

Sun, Z., Wang, Y., Chen, X., Yang, L., Li, O., Zhou, J., Tan, Z., & Peng, C. (2026). Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs.. Front Immunol, 17, 1753437. https://doi.org/10.3389/fimmu.2026.1753437

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A clinical-molecular nomogram for predicting early recurrence following resection of initially unresectable colorectal liver metastases.

BACKGROUND: Postoperative early recurrence (PER) remains a major challenge to long-term survival after successful conversion therapy and curative resection for initially unresectable colorectal liver …

Thérapies de Conversion

Lu, Y. T., Huang, X. X., Chen, W. C., Xiao, Q. Y., Duan, J. L., Li, Z. J., Pat, F. o. n. g. . W., Wang, F. H., Li, Y. H., & Wang, D. S. (2026). A clinical-molecular nomogram for predicting early recurrence following resection of initially unresectable colorectal liver metastases.. Ther Adv Med Oncol, 18, 17588359251411660. https://doi.org/10.1177/17588359251411660

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Response Rate Correlates with the Conversion Rate in Patients with Advanced Hepatocellular Carcinoma Treated with Systemic or Hepatic Artery Infusion Chemotherapy: A Systematic Review.

UNLABELLED: Introduction: The appropriate regimen for induction therapy with the intent of conversion therapy for advanced hepatocellular carcinoma (HCC) is unknown. This study aimed to evaluate wheth…

Thérapies de Conversion

Okuno, M., Nishino, H., Okura, K., Ishii, T., Hashida, H., & Hatano, E. (2026). Response Rate Correlates with the Conversion Rate in Patients with Advanced Hepatocellular Carcinoma Treated with Systemic or Hepatic Artery Infusion Chemotherapy: A Systematic Review.. Dig Surg, 43(1), 23-34. https://doi.org/10.1159/000550237

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Impact of HER2 and microsatellite instability status on response to neoadjuvant/conversion therapy and survival in patients with gastric cancer.

OBJECTIVES: The prognostic significance of microsatellite instability (MSI) and HER2 status in advanced gastric cancer (AGC) treated with neoadjuvant or conversion chemotherapy (NAC) remains unclear. …

Thérapies de Conversion

Piccioni, S. A., Costantini, M., Petrioli, R., Bagnacci, G., Ferrara, D., Andreucci, E., Carbone, L., Ongaro, A., Calomino, N., Sandini, M., Mazzei, M. A., Roviello, F., & Marrelli, D. (2026). Impact of HER2 and microsatellite instability status on response to neoadjuvant/conversion therapy and survival in patients with gastric cancer.. Eur J Cancer Prev, 35(1), 66-77. https://doi.org/10.1097/CEJ.0000000000000982

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