Neurosciences des Croyances

Cumulative social advantage is associated with slower epigenetic aging and lower systemic inflammation.

Brain Behav Immun Health . 2025;48 :101096

Résumé

BACKGROUND: Social relationships are established determinants of health across the lifespan, yet the cumulative and multidimensional effects of sustained social advantage on biological aging remain poorly understood.METHODS: Drawing on data from 2117 adults in the Midlife in the United States (MIDUS) study, we used structural equation modeling to examine whether cumulative social advantage (CSA)-a latent construct encompassing social connection across familial, religious, emotional, and community domains-was associated with epigenetic aging, systemic inflammation, and neuroendocrine activity.RESULTS: Higher CSA was linked to slower epigenetic aging, particularly as indexed by GrimAge (β = -0.09 to -0.10,  

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