TOC et Scrupulosité Religieuse

Association of rs11081062 polymorphism of gene and levels of SLC1A1 protein with obsessive-compulsive disorder.

Nucleosides Nucleotides Nucleic Acids . 2024;43 (9) :1016-1030

Résumé

Glutamate is an important neurotransmitter known to be effective in obsessive-compulsive disorder (OCD). The aim of this study is to investigate the relationship between the gene encoding the scaffold protein of ionotropic glutamate receptors and the gene encoding the glutamate transporter protein with OCD. Study groups consisted of 95 patients with OCD and 100 healthy controls. The severity of OCD in the patient group was determined by using the Y-BOCS. Single nucleotide polymorphisms of rs11081062 (C/T) in and rs587777696 (C/T) in were analyzed by real-time PCR. Levels of SLC1A1 protein were determined by ELISA. A significant difference was found between genotype distributions of rs11081062 in in study groups ( 

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