Thérapies de Conversion

Neoadjuvant or conversion therapy nullifies the prognostic impact of surgical margin width in hepatocellular carcinoma: a single-center retrospective study.

Xie H, Liao Y, Liang T, Huang H, Wei Y, Yang K, Qin C, Chen M, Song J, Zhou X, Zhou Y, Yang C, Liao X, Su H, Zhu G, Peng M, Han C, Peng's T

BMC Surg

📅 18/04/2026 PMID : 41998639 DOI : 10.1186/s12893-026-03752-z

Résumé

BACKGROUND: The prognostic role of surgical margin width in hepatocellular carcinoma (HCC) patients undergoing hepatectomy after neoadjuvant or conversion therapy remains unclear. MATERIALS AND METHODS: We retrospectively analyzed 129 HCC patients undergoing hepatectomy following neoadjuvant or conversion therapy and 720 treated with upfront surgery between 2019 and 2022. Propensity score matching (PSM) balances baseline characteristics. Disease-free survival (DFS) was evaluated by Kaplan-Meier analysis, and prognostic factors were assessed via Cox regression. RESULTS: Among patients receiving neoadjuvant or conversion therapy, DFS did not differ between wide (≥ 1 cm) and narrow (