Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy.

Résumé

SIGNIFICANCE: Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site. Current treatments have limited efficacy, and novel approaches are needed.APPROACH: We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy.RESULTS: After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). The patient successfully underwent surgical treatment.CONCLUSIONS: This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment.