Thérapies de Conversion

Preoperative assessment and prognostic prediction of gastric cancer patients with peritoneal metastasis using F-FDG PET/CT before conversion surgery.

EJNMMI Res . 2025;15 (1) :46

Résumé

BACKGROUND: Conversion therapy followed by conversion surgery (CS) can improve the prognosis of gastric cancer (GC) patients with peritoneal metastasis (PM). However, patients benefit differently. There is no way to confirm the prognostic benefit non-invasively and early. This retrospective study assessed the value of F-FDG PET/CT after conversion therapy in preoperative assessment and prognostic prediction of GC patients with PM.RESULTS: Fifty-one GC patients with PM were enrolled. F-FDG PET/CT after conversion therapy helped in preoperative assessment. Its diagnostic accuracy for residual peritoneal lesions was slightly better than contrast-enhanced CT (72.5% vs. 61.2%, P = 0.229), although the difference was not statistically significant. TBR of peritoneal lesions could help preoperative assessment, with TBR of peritoneal lesions to the mediastinal blood pool SUVmax (TBRAmaxp) as the best predictor (cutoff = 0.705, specificity 80%, sensitivity 80%, AUC 0.825, P 

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