Thérapies de Conversion

The impact of curative conversion therapy aimed at a cancer-free state in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab.

Shimose S, Iwamoto H, Shirono T, Tanaka M, Niizeki T, Kajiwara M, Itano S, Yano Y, Matsugaki S, Moriyama E, Noda Y, Nakano M, Kuromatsu R, Koga H, Kawaguchi T

Cancer Med . 2023;12 (11) :12325-12335

📅 01/06/2023 PMID : 37062077 DOI : 10.1002/cam4.5931

Résumé

BACKGROUND AND AIMS: We aimed to validate the predictive factors for tumor response and the prognostic impact of conversion therapy aimed at cancer- and drug-free states in patients with unresectable hepatocellular carcinoma (u-HCC) undergoing atezolizumab plus bevacizumab (Atez/Bev) therapy.METHODS: This retrospective study enrolled 156 patients who were Child-Pugh class A with u-HCC treated using Atez/Beva. The profile of objective response was investigated using decision-tree analysis. Progression-free, recurrence-free, and overall survival were assessed.RESULTS: The progression-free and overall survival were 6.1 and 18.0 months, respectively. Objective response and disease control rates were 32.0% and 84.0%, respectively. Decision-tree analysis revealed that neutrophil-to-lymphocyte ratio (NLR)