Belatacept, a selective costimulation blocker targeting the CD28-CD80/86 pathway, represents a major innovation in solid organ transplantation immunosuppression. By providing upstream inhibition of T-…

RATIONALE: Primary hepatic neuroendocrine carcinoma (PHNET) is an exceptionally rare malignancy with limited standardized treatment options.PATIENT CONCERNS: Two patients presented with incidentally d…

OBJECTIVE: Over the past two decades, positive psychology research has identified correlates of resilience. Although a range of strengths have been explored, there is a need to identify specific stren…

Conversion therapy remains an uncommon strategy for managing unresectable hepatocellular carcinoma (uHCC) due to limited evidence supporting its efficacy. To address this gap, we initiated a prospecti…

BACKGROUND: Adolescent loneliness and mental health have become escalating public health concerns. However, despite previous findings, research on how the school environment influences the relationshi…

: Cancer is a disabling, challenging, and growing global disease. Although early diagnosis and adequate treatment of cancer are developing rapidly, a large part of the population remains without acces…

BACKGROUND: Approximately one-third of university students are overweight or obese, and a similar proportion experience anxiety or depression. Despite the interrelated nature of weight and mental heal…

The term 'inertia' refers to the seemingly common Autistic experience of remaining in a state of rest or a state of motion until there is some form of external intervention. While a heavily discussed …

INTRODUCTION: Online community forums, like Reddit, are increasing in use by cleft patients and families as both an avenue for support and a source of medical information. This study seeks to leverage…

INTRODUCTION: Understanding how patients and health care professionals seek and interpret health information online helps to mitigate knowledge gaps at decision points, leading to improved shared deci…

BACKGROUND: Depression and active smoking are very common situations among the population, which also reduces the positive mental well-being of a person. Smoking is a global issue, and depression and …